Principal Scientist job at Azeria Therapeutics, Cambridge, UK

Azeria Therapeutics is a start-up biotech company with a focus on developing innovative new cancer medicines by targeting transcription factors. Our small molecule drug discovery approaches emanate from ground-breaking research in the laboratory of Dr Jason Carroll in the CRUK Cambridge Institute on the Cambridge Biomedical Campus. Azeria was founded in March 2017 and our translational bioscience research is conducted in modern well-equipped labs in the same building as the Carroll laboratory.

We seek a Principal Scientist to join our Bioscience Team to drive the translation of our innovative target identification platform into ‘first in class’ therapies for the treatment of cancer. The successful applicant will own and progress cell-based and in vivo pharmacology studies for biology targets revealed by innovative RIME-based approaches discovered, developed and exemplified in the Carroll laboratory. We seek a molecular biologist with at least 2 years’ post-doctoral experience in hypothesis-driven studies, to further examine the role of our identified biological targets in the initiation and progression of cancer. Knowledge and experience of transcription factor and hormone-dependent cancer biology are highly desirable, but not essential. The role will involve extensive collaboration with the Carroll laboratory and with our network of expert partners to progress our drug discovery projects through proof-of-concept in vivo studies and beyond. 

The successful applicant will be expected to accelerate progress in biology understanding of at least one drug discovery target through their own initiative and independent practical laboratory contribution. They will also be expected to constructively contribute both intellectually and practically, as time allows, to other Azeria Projects. The role reports to an Associate Director of Discovery Biology and will work closely with the current team of cancer biologists in a highly integrated working environment. 

Applicants must have a PhD in biological sciences and at least 2 years Post-Doctoral experience in a translational research-based laboratory environment. You will be highly organised and an excellent communicator with a flexible and cooperative approach to working in a team environment.

This permanent, full-time position is based at the CRUK Cambridge Institute with travel to partner CROs, collaborators and consultants as required.  The successful applicant will be offered a competitive salary based on experience.

Applicants must be able to demonstrate proof of the right to work in the United Kingdom. 

Applicants must include a covering letter with a description of their background and interest in the role, a one-page research summary for each of their PhD and Post-Doctoral studies highlighting their independent contributions and impacts, and a curriculum vitae including publications, manuscripts in preparation and contact details for at least two referees

For more information and to apply please contact: admin@azeriatherapeutics.com

Closing date: 27 June 2019

Person specification

Education and knowledge

  • PhD in biological sciences 
  • Post-doctoral studies in cancer biology
  • Knowledge of transcription factor and hormone-dependent cancer biology

Experience

  • At least 2 years of hands-on post-doctoral research in cancer biology
  • Evidence for significant, independent intellectual and practical contribution to problem-solving in both PhD and post-doctoral work.
  • Evidence for the successful exemplification of high-quality scientific achievement in manuscripts and/or oral presentation
  • Experience of hypothesis-driven cell-based and/or in vivo profiling of small molecule chemical tools and drugs.
  • Experience of biomarker discovery 
  • Experience in bioscience research in the biotech or pharmaceutical drug discovery sectors

Skills

  • Well-trained, independent and proficient in cell/tissue culture, Western blotting, cell viability assays and in general molecular biology techniques (PCR/qPCR, cloning)
  • Good understanding of phenotypic screening methodologies and practical experience thereof 
  • Good understanding and practical experience of technologies to study protein-protein and protein-DNA interactions (E.g. ChIP-seq, PLA, Co-IP) 
  • Experience in bioinformatics applied to data analysis and mining in translational research  
  • Evidence for independent design and execution of hypothesis-testing biological experiments and associated contingency plans
  • Highly organised with evidence for successful time-management and working to deadlines 
  • Active listening skills that enable effective implementation of plans agreed in team discussions
  • Excellence and clarity in both oral and written communication.
  • Excellent interpersonal skills for building and maintaining good working relationships both within the Azeria team and with partner CROs and collaborators. 

General

  • Evidence for a flexible and cooperative approach to working in a dynamic and collaborative team environment.
  • Strong desire to work in a fast-moving small molecule-focused translational research environment bridging both commercial and academic research.